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Informatically-informed biochemical characterization of aptamer-protein complexes
(University of Missouri--Columbia, 2022)
Nucleic acid aptamers are single-stranded oligonucleotides that fold into unique three-dimensional shapes that typically bind to targets of interest with high specificity and high affinity. However, a significant limiting ...
Cryo-EM reveals how adeno-associated virus engages its receptor AAVR and an investigation of the GPR108 ectodomain
(University of Missouri--Columbia, 2022)
Adeno-associated virus is one of the leading delivery agents used in gene therapy today. While it is already used in the clinic, some aspects of its basic biology are still not yet fully understood. Only recently in 2017 ...
Roles of post-Golgi vesicular trafficking components in plant growth and immunity
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] Delineating the molecular mechanisms of plant immunity can help inspire novel ways to engineer more resistant plants which could contribute to reducing crop loss due to pathogenic infection. The ...